Selected papers (full or short) will be invited to produce an extended paper, based on the paper published in STC2021, to be submitted for consideration of publication in a Focus Theme of the journal “Methods of Information in Medicine”. With respect to the STC2021 paper, the extended paper should be longer, more detailed, and with more results and discussions, so a rather different paper based on the first one. The Focus Theme will only contain papers from STC2021 authors. Dates and instructions for the submission process will be announced to the authors of the selected papers. “Methods of Information in Medicine” offers two separate submission tracks: a) print only, free of charge for articles with up to 22,000 characters, and b) open access with an APC fee of 1,650 € per article. Authors may choose their submission method of preference and the Focus Theme will be bundled online at the journal’s website.